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TOP > What's Glycine? > Physiological functions
What's Glycine?
Physiological functions
Metabolism
In human Glycine is mainly metabolized as follows.
Glycine+Tetrahydrofolic acid+NAD+

CO2+NH3+Methylenetetrahydrofolate+NADH+H+

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Bioactive substances
Glycine is a constituent of various bioactive substances;
1) Glutathione, an anti-oxidant,  is a tri-peptide of γGlu-Cys-Gly.
2) Gly, Arg, and Met are converted to Creatine which stores energy in the body.
3) The heme in Haemoglobin is synthesized from Glycine and succinyl-CoA.
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Neurotransmitter
Certain amino acids, amines, and peptides can be neurotransmitters. Glycine is one of them.
Excitatory transmitter
Glutamic acid
Inhibitory transmitter
γ-aminobutyric acid (GABA),
Glycine
GABA has a relaxation effect. Since Glycine is also a inhibitory neurotransmitter, it has a similar effect.
It is reported that a deep sleep can be promoted by Glycine supplementation. This function of Glycine has been commercialized.
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