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In human Glycine is mainly metabolized as follows.
Glycine+Tetrahydrofolic acid+NAD+
↓
CO2+NH3+Methylenetetrahydrofolate+NADH+H+
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Glycine is a constituent of various bioactive substances;
1) Glutathione, an anti-oxidant, is a tri-peptide of γGlu-Cys-Gly.
2) Gly, Arg, and Met are converted to Creatine which stores energy in the body.
3) The heme in Haemoglobin is synthesized from Glycine and succinyl-CoA. |
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