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TOP > What's Glycine? > Function
What's Glycine?
Function
Metabolism
Glycine is mainly metabolized as follows.
Glycine+Tetrahydrofolic acid+NAD+
↓
CO2+NH3+Methylenetetrahydrofolate+NADH+H+

Tetrahydrofolic acid acts on nucleic acid base composition, amino acid metabolism, etc. as coenzyme of C1 unit transition enzyme.
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Bioactive substances
Glycine is source of various bioactive substances.
Glutathione with effect of anti-oxidization and detoxification is peptide of γGlu-Cys-Gly.
Gly, Arg, and Met are converted to creatine which stores energy in the body.
The heme in erythrocyte is biosynthesized from Glycine and succinyl-CoA.
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Neurotransmitter
There are amino acid, amine, and peptide in neurotransmitter. Glycine is one of the neurotransmitter.
Excitatory transmitter
 Glutamic acid
Inhibitory transmitter
 γ-aminobutyric acid (GABA),
Glycine
GABA has relaxation effect. Since Glycine is also inhibitory neurotransmitter, the same effect is expectable.
It is reported that a deep sleep is promoted by Glycine ingestion, and it is commercialized.
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