YUKI GOSEI KOGYO CO.,LTD.YUKI GOSEI KOGYO CO.,LTD.

Contract Manufacturing of Chemical Products
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Contract Manufacturing of Chemical Products

Manufacturing of products that meet customer needs, with our expertise and specialized facilities

Our system is designed to meet various contract manufacturing needs. We supply highly reliable products under the quality assurance system unique to YUKI GOSEI KOGYO

Advantages of contract manufacturing

・Business continuity (decentralization of production) can be ensured in emergencies.
・Production using our facilities allows customers to avoid substantial investment in manufacturing facilities.
・Our reliable product management capability allows customers to reduce costs for managing the manufacturing process.
・Customer’s human resources can be used effectively and efficiently.

Strengths of YUKI GOSEI KOGYO CO.,LTD.

Firstly, we produce a small volume of products on a trial basis, based on our research achievements and facilities.
We then identify where to improve in the prototype based on an assessment by the customer.
We also hold discussions to find an optimal mass production system to commercialize the product and develop a plan for commercialization. The most efficient manufacturing method is then selected.
After agreement from the customer, a contract will be signed and high-quality mass production will be started.

Flow of contract manufacturing

  • Consultation/request from a customer Respond quickly and accurately to a request based on in-depth communication
  • Research and development We identify the manufacturing method and make a development plan according to the customer’s request. We propose a manufacturing method, quality, costs, and the due date that are most suitable to the customer.
  • Trial production Produce a small volume of products on a trial basis and discuss what should be improved with the customer
  • Contract signing and full-scale manufacturing Efficiently produce the product on a large scale at our plant to be supplied as agreed

Major manufacturing technology

Grignard reaction, esterification, alkylation, alkoxylation, acylation, amination, amidation, diazotization, cyanation, condensation reactions, reductions, etc.

* We identify an optimal manufacturing method, obtain approval for pharmaceutical manufacturing, prepare DMF, make registrations, and manufacture products on a commercial scale under a quality control system that complies with GMP and ISO 9000 standards.

Facilities

Click here for a list of facilities essential to manufacturing products, such as reaction vessels and pressure containers, and crushing devices essential to manufacturing pharmaceutical products.

Crushing/pulverizing facilities

Medical counter jet mills for ultrafine particles with a diameter less than 10 microns are also available.

Major facilities (GMP-compliant)

Facilities Material Size Quantity Remarks
Reaction vessel GL 8,000L 1  
GL 6,000L 3  
GL 3,000L 3  
GL 2,000L 3  
GL 1,500L 1  
GL 1,000L 2  
GL 600L 1  
GL 500L 2  
GL 300L 2  
GL 200L 1  
SUS 6,000L 1  
SUS 3,000L 1  
SUS 1,000L 4  
SUS 600L    
SUS 300L 1  
SUS 150L 1  
Hydrogenation kettle GL 3,000L 1 Hydrogen pressure:≦ 1.0 MPa
Crystallization kettle GL,SUS GL, SUS Various sizes Many ~6,000L
Distillation kettle GL,SUS Various sizes Many ~6,000L
Receiver, etc. GL,SUS Various sizes Many Distillation receiver, dissolver, settling tank, equalizing tank, etc.
Filter GL,SUS Various sizes Many  
Centrifugal separator   Various sizes Many Top discharge type, bottom discharge type, fully automatic type, aflon, SUS
Dryer GL,SUS Various sizes Many Vacuum tornado type, conical type, vibration fluidizing type
Clean room   4 Class 100,000
Pharmaceutical liquid manufacturing facilities     1 USP-compliant

Small-sized machine

Name Type Specifications (nominal) Remarks
Particle size distribution Capability/h
Hammer mill Hosokawa Micron Fine Impact Mill 100 UPZ 20~700µm 2~30kg Plate beater
Hammer beater
Three kinds of pin mills

Manufacturing machines

Name Type Specifications (nominal) Remarks
Particle size distribution Capability/h
Jet mill Hosokawa Counter Jet Mill 200AFG-pharma 2~20µm 20~30kg Medium: Nitrogen 400 Nm3/h
Jet mill Hosokawa Micron Spiral Jet Mill 200AS 1~5µm 10~30kg Medium: Nitrogen 400 Nm3/h

Specifications of the pulverization clean room

Class 100,000
Temperature 23±5℃
Humidity 45±15%

Crushing/pulverizing facilities

Medical counter jet mills for ultrafine particles with a diameter less than 10 microns are also available.

Small-sized machine

Name Hammer mill
Type Hosokawa Micron Fine Impact Mill 100 UPZ
Specifications
(nominal)
Particle size distribution
20~700µm
Capability/h
2~30kg
Remarks Plate beater
Hammer beater
Three kinds of pin mills

Manufacturing machines

Name Jet mill Jet mill
Type Hosokawa Counter Jet Mill 200AFG-pharma Hosokawa Micron Spiral Jet Mill 200AS
Specifications
(nominal)
Particle size distribution
2~20µm
Particle size distribution
2~20µm
Capability/h
20~30kg
Capability/h
20~30kg
Remarks Medium: Nitrogen 400 Nm3/h Medium: Nitrogen 400 Nm3/h

Specifications of the pulverization clean room

Class 100,000
Temperature 23±5℃
Humidity 45±15%

Major facilities (GMP-compliant)

Facilities Material Quantity Remarks
Reaction vessel GL 8,000L 1
GL 6,000L 3
GL 3,000L 3
GL 2,000L 3
GL 1,500L 1
GL 1,000L 2
GL 600L 1
GL 500L 2
GL 300L 2
GL 200L 1
SUS 6,000L 1
SUS 3,000L 1
SUS 1,000L 4
SUS 600L 1
SUS 300L 1
SUS 150L 1
Hydrogenation kettle GLL 3,000 1
Hydrogen pressure: ≦ 1.0 MPa
Crystallization kettle GL,SUS Various sizes Many
~6,000L
Distillation kettle GL,SUS Various sizes Many
~6,000L
Receiver, etc. GL,SUS Various sizes Many
Distillation receiver, dissolver, settling tank, equalizing tank, etc.
Filter GL,SUS Various sizes Many
Centrifugal separator   Various sizes Many
Top discharge type, bottom discharge type, fully automatic type, aflon, SUS
Dryer GL,SUS Various sizes Many
Vacuum tornado type, conical type, vibration fluidizing type
Clean room     4
Class 100,000
Pharmaceutical liquid manufacturing facilities     1
USP-compliant

We meet diverse needs of customers.

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