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- Contract Manufacturing of Chemical Products
Contract Manufacturing of Chemical Products
Manufacturing of products that meet customer needs, with our expertise and specialized facilities
Our system is designed to meet various contract manufacturing needs. We supply highly reliable products under the quality assurance system unique to YUKI GOSEI KOGYO
Advantages of contract manufacturing
・Business continuity (decentralization of production) can be ensured in emergencies.
・Production using our facilities allows customers to avoid substantial investment in manufacturing facilities.
・Our reliable product management capability allows customers to reduce costs for managing the manufacturing process.
・Customer’s human resources can be used effectively and efficiently.
Strengths of YUKI GOSEI KOGYO CO.,LTD.
Firstly, we produce a small volume of products on a trial basis, based on our research achievements and facilities.
We then identify where to improve in the prototype based on an assessment by the customer.
We also hold discussions to find an optimal mass production system to commercialize the product and develop a plan for commercialization. The most efficient manufacturing method is then selected.
After agreement from the customer, a contract will be signed and high-quality mass production will be started.
Flow of contract manufacturing
- Consultation/request from a customer Respond quickly and accurately to a request based on in-depth communication
- Research and development We identify the manufacturing method and make a development plan according to the customer’s request. We propose a manufacturing method, quality, costs, and the due date that are most suitable to the customer.
- Trial production Produce a small volume of products on a trial basis and discuss what should be improved with the customer
- Contract signing and full-scale manufacturing Efficiently produce the product on a large scale at our plant to be supplied as agreed
Major manufacturing technology
Grignard reaction, esterification, alkylation, alkoxylation, acylation, amination, amidation, diazotization, cyanation, condensation reactions, reductions, etc.
* We identify an optimal manufacturing method, obtain approval for pharmaceutical manufacturing, prepare DMF, make registrations, and manufacture products on a commercial scale under a quality control system that complies with GMP and ISO 9000 standards.
Facilities
Crushing/pulverizing facilities
Medical counter jet mills for ultrafine particles with a diameter less than 10 microns are also available.
Major facilities (GMP-compliant)
Facilities | Material | Size | Quantity | Remarks |
---|---|---|---|---|
Reaction vessel | GL | 8,000L | 1 | |
GL | 6,000L | 3 | ||
GL | 3,000L | 3 | ||
GL | 2,000L | 3 | ||
GL | 1,500L | 1 | ||
GL | 1,000L | 2 | ||
GL | 600L | 1 | ||
GL | 500L | 2 | ||
GL | 300L | 2 | ||
GL | 200L | 1 | ||
SUS | 6,000L | 1 | ||
SUS | 3,000L | 1 | ||
SUS | 1,000L | 4 | ||
SUS | 600L | |||
SUS | 300L | 1 | ||
SUS | 150L | 1 | ||
Hydrogenation kettle | GL | 3,000L | 1 | Hydrogen pressure:≦ 1.0 MPa |
Crystallization kettle | GL,SUS | GL, SUS Various sizes | Many | ~6,000L |
Distillation kettle | GL,SUS | Various sizes | Many | ~6,000L |
Receiver, etc. | GL,SUS | Various sizes | Many | Distillation receiver, dissolver, settling tank, equalizing tank, etc. |
Filter | GL,SUS | Various sizes | Many | |
Centrifugal separator | Various sizes | Many | Top discharge type, bottom discharge type, fully automatic type, aflon, SUS | |
Dryer | GL,SUS | Various sizes | Many | Vacuum tornado type, conical type, vibration fluidizing type |
Clean room | 4 | Class 100,000 | ||
Pharmaceutical liquid manufacturing facilities | 1 | USP-compliant |
Small-sized machine
Name | Type | Specifications (nominal) | Remarks | |
---|---|---|---|---|
Particle size distribution | Capability/h | |||
Hammer mill | Hosokawa Micron Fine Impact Mill 100 UPZ | 20~700µm | 2~30kg | Plate beater Hammer beater Three kinds of pin mills |
Manufacturing machines
Name | Type | Specifications (nominal) | Remarks | |
---|---|---|---|---|
Particle size distribution | Capability/h | |||
Jet mill | Hosokawa Counter Jet Mill 200AFG-pharma | 2~20µm | 20~30kg | Medium: Nitrogen 400 Nm3/h |
Jet mill | Hosokawa Micron Spiral Jet Mill 200AS | 1~5µm | 10~30kg | Medium: Nitrogen 400 Nm3/h |
Specifications of the pulverization clean room
Class | 100,000 |
---|---|
Temperature | 23±5℃ |
Humidity | 45±15% |
Crushing/pulverizing facilities
Medical counter jet mills for ultrafine particles with a diameter less than 10 microns are also available.
Small-sized machine
Name | Hammer mill |
---|---|
Type | Hosokawa Micron Fine Impact Mill 100 UPZ |
Specifications (nominal) |
Particle size distribution 20~700µm |
Capability/h 2~30kg |
|
Remarks | Plate beater Hammer beater Three kinds of pin mills |
Manufacturing machines
Name | Jet mill | Jet mill |
---|---|---|
Type | Hosokawa Counter Jet Mill 200AFG-pharma | Hosokawa Micron Spiral Jet Mill 200AS |
Specifications (nominal) |
Particle size distribution 2~20µm |
Particle size distribution 2~20µm |
Capability/h 20~30kg |
Capability/h 20~30kg |
|
Remarks | Medium: Nitrogen 400 Nm3/h | Medium: Nitrogen 400 Nm3/h |
Specifications of the pulverization clean room
Class | 100,000 |
---|---|
Temperature | 23±5℃ |
Humidity | 45±15% |
Major facilities (GMP-compliant)
Facilities | Material | Quantity | Remarks |
---|---|---|---|
Reaction vessel | GL | 8,000L | 1 |
GL | 6,000L | 3 | |
GL | 3,000L | 3 | |
GL | 2,000L | 3 | |
GL | 1,500L | 1 | |
GL | 1,000L | 2 | |
GL | 600L | 1 | |
GL | 500L | 2 | |
GL | 300L | 2 | |
GL | 200L | 1 | |
SUS | 6,000L | 1 | |
SUS | 3,000L | 1 | |
SUS | 1,000L | 4 | |
SUS | 600L | 1 | |
SUS | 300L | 1 | |
SUS | 150L | 1 | |
Hydrogenation kettle | GLL | 3,000 | 1 |
Hydrogen pressure: ≦ 1.0 MPa | |||
Crystallization kettle | GL,SUS | Various sizes | Many |
~6,000L | |||
Distillation kettle | GL,SUS | Various sizes | Many |
~6,000L | |||
Receiver, etc. | GL,SUS | Various sizes | Many |
Distillation receiver, dissolver, settling tank, equalizing tank, etc. | |||
Filter | GL,SUS | Various sizes | Many |
Centrifugal separator | Various sizes | Many | |
Top discharge type, bottom discharge type, fully automatic type, aflon, SUS | |||
Dryer | GL,SUS | Various sizes | Many |
Vacuum tornado type, conical type, vibration fluidizing type | |||
Clean room | 4 | ||
Class 100,000 | |||
Pharmaceutical liquid manufacturing facilities | 1 | ||
USP-compliant |